As an artist, Karina Synytsia works primarily with painting, with a particular focus on monumental techniques, especially wall painting. Her works depict architectural structures and landscapes, emphasizing emptiness, void, and the decline of spaces and objects. However, architectural elements in her pieces appear as decorations of urban environments rather than central subjects. Instead, the core of her works lies in the manifestation of human emotions, emotional states, and social aspects of life.
Her works are featured in the second edition of the Ukrainian section of the Secondary Archive, as well as in archival projects "The Sky Is Open. Voices From Ukraine" and "Ukraine Ablaze" (by the Mala Gallery of Mystetskyi Arsenal).